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There is no specific antidote for dutasteride. Therefore, in cases of suspected overdosage, symptomatic and supportive treatment should be given as appropriate, taking the long half-life of dutasteride into consideration. Avodart Description Avodart is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase, an intracellular enzyme that buys Avodart 0.5 mg Pharmacy testosterone to DHT.
The inactive excipients in the capsule shell are ferric oxide buy Avodart 0.5 mg Pharmacy, gelatin from certified BSE-free bovine sources, glycerin, and titanium dioxide. The soft gelatin capsules are printed buy Avodart 0.5 mg Pharmacy edible red ink. DHT is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely buy Avodart 0.5 mg Pharmacy. Dutasteride does not bind to the human androgen receptor. In patients with BPH treated with dutasteride 0. These 5 alpha-reductase deficient males have a small prostate gland throughout life and do not develop BPH.
Except for the associated urogenital defects present at birth, no other clinical abnormalities related to 5 alpha-reductase-deficiency have been observed in these individuals. The median percentage changes from baseline within the dutasteride buy Avodart 0.5 mg Pharmacy were 17. There was no change in bone mineral density as measured by dual energy x-ray absorptiometry compared with either placebo or baseline.
In addition, the plasma lipid profile i. This reduction is of no clinical significance. Dutasteride is highly bound to plasma albumin 99. Metabolism and Elimination Dutasteride is extensively metabolized in humans. In addition, the 15-hydroxydutasteride metabolite was formed by CYP3A4. Dutasteride and its metabolites were excreted mainly in feces. No dose adjustment is necessary in the elderly. No overall differences in safety or efficacy were observed between these patients and younger patients. Avodart is contraindicated in pregnancy and women of childbearing potential and is not indicated for use in other women [see Contraindications 4, Warnings and Precautions 5. The pharmacokinetics of dutasteride in women have not been studied.
The effect of race on dutasteride pharmacokinetics has not been studied. The effect of renal impairment on dutasteride pharmacokinetics has not been studied. However, less than 0. The buy Avodart 0.5 mg Pharmacy of hepatic impairment on dutasteride pharmacokinetics has not been studied. The decrease in clearance and subsequent increase in exposure to dutasteride in the presence of verapamil and diltiazem is not considered to be clinically significant.
No dose adjustment is bought Avodart 0.5 mg Pharmacy. The exposure to these metabolites in mice is either buy Avodart 0.5 mg Pharmacy than in humans or is not known. In a 2-year carcinogenicity study in Han Wistar rats, at doses of 1. An increased incidence of Leydig cell hyperplasia was present at 52-fold the MRHD male rat doses of 7. A positive correlation between proliferative changes in the Leydig cells and an increase in circulating luteinizing hormone levels has been demonstrated with 5 alpha-reductase inhibitors and is consistent with an effect on the hypothalamic-pituitary-testicular axis following 5 alpha-reductase inhibition. Buy Avodart Pharmacy Sale!
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